Biofabrication is the process of artificially creating organs and biotissues from cells and tissue spheroids. Currently, one of the most crucial issues in biofabrication is vascularization of artificial organs, i.e., creating thin hollow vessels for them.
Ultrasound is able to contactlessly manipulate objects using acoustic radiation force. Therefore, a combination of acoustic and magnetic fields makes it possible to contactlessly organize cells into hollow tubes to create artificial vessels.
LIMU tasks
- Numerical calculations of the impact of complex beams on tissue spheroids
- Verification experiments with phantoms and constructs of living cells (in collaboration with “3D Bioprinting Solutions”)
Activity types
- numerical modeling
- experiments with living cell constructs
Contacts
[1] Biofabrication of a functional tubular construct from tissue spheroids using magnetoacoustic levitational directed assembly / Parfenov V.A., Koudan E.V., Krokhmal A.A., Annenkova E.A., Petrov S.V., Pereira F.D.A.S, Karalkin P.A., Nezhurina E.K., Gryadunova A.A., Bulanova E.A., Sapozhnikov O.A., Tsysar S.A., Liu K., Oosterwijk E., van Beuningen H., van der Kraan P., Granneman S., Engelkamp H., Christianen P., Kasyanov V., Khesuani Y.D., Mironov V.A. // Advanced healthcare materials. 2020. P. 2000721-1 – 2000721-10. DOI: 10.1002/adhm.202000721
[2] Creating tubular structures from tissue spheroids via the acoustic radiation force / A. A. Krokhmal, O. A. Sapozhnikov, E. V. Koudan et al. // Bulletin of the Russian Academy of Sciences: Physics. — 2021. — Vol. 85, no. 6. — P. 681–685. DOI: 10.3103/s1062873821060137